1 Acquired Immunity Hugh B Fackrell filename Kuby
1 Acquired Immunity Hugh B. Fackrell filename : Kuby 01 B 7 2/27/2021
2 Acquired Immunity: Outline ä Acquired vs Innate Immunity ä Functions of Acquired Immunity ä Humoral Immunity: antibody ä Cell Mediated Immunity ä Role of Macrophages ä Regulation of Immunity ä Next 2/27/2021
3 Acquired Immunity: Definitions ä Acquired Immunity ä Antigen ä Immunogen ä Humoral Immunity ä Cell Mediated Immunity ä Next 2/27/2021
4 Acquired Immunity: Objectives ä Define the following terms: Antigen, immunogen, acquired immunity, humoral immunity, cell mediated immunity ä Identify the cells of the acquired immune response from light or electron micrographs ä Identify the functions of the cells of the acquired immune reponse ä Next 2/27/2021
5 Acquired Immunity ä Definition ä Acquired immunity( AKA adaptive immunity) is an altered reactivity to a specific compound after exposure to that compound ä Characteristics ä Specificity ä Memory ä Next 2/27/2021
6 Acquired Immunity Important Features ä ä The altered reactivity will not be to all compounds, just those compounds to which the animal has been exposed The animal has a heightened specific response on second and subsequent exposures because the body ” remembers” previous contacts ä Next 2/27/2021
7 Functions of Acquired Immunity Discriminate between self and non self for: ä Defense ä destruction of foreign molecules ä Homeostasis ä removal of dead or damaged cells ä Surveillance ä control of mutant or cancer cells ä Next 2/27/2021
8 Acquired Immunity has Two Forms ä Humoral Immunity ä lymphocytes react INDIRECTLY on non self molecules via antibodies ä Cell Mediated Immunity ä Lymphocytes act DIRECTLY on the non self molecules ä Next 2/27/2021
9 Lymphocytes 2/27/2021
10 Immunogen vs Antigen ANTIGEN: combines with the products of an immune response IMMUNOGEN: triggers immunity and combines with products 2/27/2021
11 Antigen: interaction 2/27/2021
12 Remember ä Immunogenicity is not an inherent characteristic of a molecule ä Immunogen MUST first be recognized as foreign by the body ä Next 2/27/2021
13 Adaptive vs Innate Immunity 2/27/2021
14 Primary vs Secondary Responses 2/27/2021
15 Humoral Immunity 2/27/2021
16 Antibodies Distinguish Between ä Diseases ä measles & mumps ä Macromolecules ä proteins, complex carbohydrates ä Molecules ä amino acids, sugars ä Submolecular Structures ä D& L isomers; ortho, meta, para positions ä Next 2/27/2021
17 B cell blasts 2/27/2021
18 B Cell Transformation 2/27/2021
19 Clonal Selection: B cells 2/27/2021
20 Immunglobulin on B cells 2/27/2021
21 Plasma cell function 2/27/2021
22 Antibody: a Flexible mediator 2/27/2021
23 Plasma cell: function 2/27/2021
24 Complement functions 2/27/2021
25 Cell Mediated Immunity 2/27/2021
26 T cell blasts 2/27/2021
27 T cell blasts: structure 2/27/2021
28 T cells 2/27/2021
29 Cell mediated clonal selection 2/27/2021
30 T cell transformation 2/27/2021
31 T cells ANAE stain 2/27/2021
32 Role of Macrophages 2/27/2021
33 Monocyte 2/27/2021
34 Monocyte structure 2/27/2021
35 Macrophage Activation products 2/27/2021
36 Macrophages & T cells 2/27/2021
37 T cells interacting with Macrophage 2/27/2021
38 Macrophage mediatiors: CD 14 receptor 2/27/2021
39 Macrophage mediators: CD 14 & LPS receptors 2/27/2021
40 Endotoxin induction of Macrophage mediators: direct induction 2/27/2021
41 Oponsization: mechanisms 2/27/2021
42 Regulation of Immunity 2/27/2021
43 Range of immune responses 2/27/2021
44 Antigen Processing 2/27/2021
45 Cellular interactions during the humoral response 2/27/2021
46 A Complete Immune Response ä Lymphocytes ä B cells ä T cells ä Macrophages ä critical accessory cells ä Complement ä combines with antibody to enhance destruction ä Next 2/27/2021
47 White Blood Cells 2/27/2021
48 Adverse effects of Immunity 2/27/2021
49 The End 2/27/2021
50 Acquired Immunity: Questions ä How does clonal selection contribute to memory in the immune response? ä Name three feature of a secondary immune response that make it different from a primary immune response. 2/27/2021
51 Questions(1) ä Interleukin 2 is a nonspecific growth factor that stimulates the growth of TH cells during the immune response. In view of this nonspecificity of IL-2, what mechanism assures that only TH cells specific for a given antigen proliferate and that all other TH cells do not proliferate 2/27/2021
52 Questions (2) ä Antigen presenting cells play a role in both humoral and cell mediated immune responses ä Name three type af antigen presenting cells ä Which class of MHC molecules are expressed on the membrane of antigen presenting cells? ä Which lymphocytes interact eith antigen presenting cells? 2/27/2021
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